| abstract |
FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to the novel amino-derivatives of the formula (I) where R 1 -R 4 are hydrogen atoms; X is alkylene with 1-6 carbon atoms; Y is lower alkyl; B means NR 5 R 11 where R 5 is hydrogen atom; R 11 is taken among 5-6-membered heterocyclic radical where one ring member is carbon and 1-4 members are nitrogen or sulfur heteroatoms, or their pharmaceutically acceptable salts that can be useful as inhibitors of synthesis of nitrogen oxide. Invention proposes also method of inhibition of synthesis of nitrogen oxide, method of selective inhibition of synthesis of nitrogen oxide produced by inducible NO- -synthase, method of decrease of nitrogen oxide level and pharmaceutical composition. EFFECT: improved method of inhibition and decrease of nitrogen oxide level. 6 cl, 1 tbl, 7 ex |