| abstract |
FIELD: medicine. SUBSTANCE: method involves administration to humans of 2-phenyl-3-aroylbenzothio-phene and bis-phosphonate or their acceptable salts or solvates. Alendronate, pomidronate, risedronate, cycloheptyl-aminomethylidene bis-phosphonate and others can be used as bis-phosphonate. [6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thiene-3-yl]-[4-[2-(1-piperidinyl)ethoxy] phenyl]-methanone, its salts and solvates and others compounds are used as 2-phenyl-3-aroyl-benzothiophene. Pharmaceutical preparation has 2-phenyl-3-aroylbenzothiophene and bis-phosphonate or their acceptable salts or their solvates. Combined administration of compounds of two indicated types enhances effectiveness of treatment and decreases possible undesirable adverse effects. Invention can be used for treatment of patients with osseous disorders, in part, with postclimacteric and senile osteoporosis. EFFECT: enhanced effectiveness of treatment, decreased adverse effects. 9 cl, 10 tbl |