| abstract |
FIELD: organic chemistry, pharmacology. SUBSTANCE: invention proposes a new antagonist of tachykinin binding with tachykinin receptors. Invention relates to the known antiestrogen of the formula (I): where R 1 and R 3 mean independently hydrogen atom, methyl, or where Ar is optionally substituted phenyl; R 2 is taken among the group involving pyrrolidine group and piperidine group; or its pharmaceutically acceptable salts. EFFECT: broadened arsenal of agents. 4 cl, 1 tbl |