| titleOfInvention |
Derivatives of benzothiophene, benzofuran, indolethiazepinone, oxazepinone and diazepinone, pharmaceutical composition showing activity inhibiting cellular adhesion or hiv-activity, method of inhibition of leukocyte adhesion to endothelial cells in treatment of diseases caused with its, method of treatment of mammals infected with hiv-infection |
| abstract |
FIELD: organic chemistry, virology, pharmacy. SUBSTANCE: invention describes the novel derivatives of benzothiophene, benzofuran, indolethiazepinone, oxazepinone and diazepinone of the formula (I) where: R 1 -R 6 , X and Y have values given in p. 1 of the invention claim, and their pharmaceutically acceptable acid-additive salts. The proposed heterocyclic compounds can be used as an active component of a pharmaceutical composition showing capacity to inhibit cellular adhesion or HIV-activity. Except for, these compounds can be used for inhibition of leukocytes adhesion to endothelial cells in treatment of sicknesses caused with its, for example, inflammatory sickness and also for treatment of humans and animals infected with HIV-infection. EFFECT: new compounds indicated above, enhanced effectiveness of treatment. 15 cl, 2 tbl, 12 ex |