| abstract |
FIELD: organic synthesis and biologically-active compounds. SUBSTANCE: invention provides new pyrido[3,2-e] pyrazinones of general formula I: (I), wherein X, Y, and Z are nitrogen or group CR 3 , provided that at least one of X, Y, Z is nitrogen; R 1 is optionally aryl- substituted C 1 -C 10 -alkyl; R 2 hydrogen, C 5 -C 7 -cycloalkyl, or C 1 -C 10 -alkyl optionally substituted by radical selected from group including aryl, aryloxy, hydroxyl, sulfonyl, pyridyl, and quinolyl; A is methylene, group NR 3 , or oxygen atom; R 3 hydrogen or C 1 -C 6 -alkyl; or their physiologically tolerable salts exhibiting anti-asthmatic and antiallergenic effects. EFFECT: increased choice of pharmaceutically active compounds. 8 cl, 2 tbl, 53 ex |