http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2141957-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_da155002c69cc08aa801a429b2ae00df |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 |
| filingDate | 1995-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_356fa04e0ea5021cce274808b8914da5 |
| publicationDate | 1999-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2141957-C1 |
| titleOfInvention | Method of synthesis of 3-hydroxy-5-[2-(dimethylamino)-ethyl]- -2,3-dihydro-4-(methoxyphenyl)-1,5-benzothiazepine-4-(5h)-on'e method of synthesis of benzothiazepine derivatives, method of synthesis of cis-(+)-3-acetoxy-5-[2-(dimethylamino)-ethyl]- -2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepine-4-(5h)-on'e |
| abstract | FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to a method of synthesis of 3-hydroxy-5- -[2-(dimethylamino)-ethyl]-2,3-dihydro-4-(methoxyphenyl)-1,5- -benzothiazepine-4-(5H)-on'e of the general formula (I) and its salts that can be used for synthesis of pharmaceutically active compounds, for example, diltiazem that is used in cardiovascular therapy. Method involves the reaction of N-alkylation of 3-hydroxy-2,3-dihydro-4-(methoxyphenyl)-1,5- -benzothiazepine-4-(5H)-on'e of the formula (II) with (dimethylamino)-ethyl halide and this reaction of N-alkylation is carried out in the reaction mixture containing 2-butanol and water. EFFECT: simplified method, increased effectiveness and safety as compared with the known ones, high purity of the end product. 11 cl, 2 ex |
| priorityDate | 1994-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.