| abstract |
FIELD: organic chemistry, pharmacy, virology. SUBSTANCE: invention describes new phenoxyalkylthiadiazoles of the general formula (I) where This means thiadiazolyl or substituted thiadiazolyl and containing as a substituent alkoxy-, fluoromethyl-, trifluoromethyl-, 1,1-difluoroethyl-group, halogen atom, alkyl-, cycloalkyl-, hydroxyalkyl- or alkoxyalkyl-group; Y is an alkylene bridge containing 3-9 carbon atoms; R 1 and R 2 each independently is taken among hydrogen, halogen atom, alkyl, hydroxyl, hydroxyalkyl, alkoxyalkyl, alkoxy-, nitro-, carboxy-group, alkoxycarbonyl, difluoromethyl or trifluoro-methyl; R 3 means phenyl or heterocyclic radical that is taken among the group including benzoxazolyl, benzothiazolyl, thiadiazolyl, oxazolyl, thiazolyl, oxadiazolyl-isoxazolyl, furyl, thienyl, pyridyl or substituted phenyl or substituted heterocycle containing as a substituent the following groups: alkyl, alkoxyalkyl, cycloalkyl, halogenalkyl, hydroxyalkyl, alkoxy-, hydroxy-group or fluoroalkyl or its pharmaceutically acceptable acid-additive salts. The above indicated compounds show an antipicornaviral activity. Invention describes also a method of prophylaxis and treatment and a method of control of picornaviruses. EFFECT: enhanced antipicornaviral activity of compounds. 23 cl, 1 tbl, 8 ex |