| abstract |
FIELD: pharmaceutical chemistry. SUBSTANCE: invention relates to orally supplying peptide and protein pharmaceutics involving vitamin B 12 absorption system amplified by polymers. In particular, complex (Y-O) n -P-(O′-A) m , is utilized, wherein Y denotes carrier to be bound to natural internal factor: vitamin B or its analog, n is coefficient of molar substitution of Y in complex and ranges from 1.0 to approximately 10; P denotes pharmaceutically acceptable polymer; A pharmaceutically active substance; m is coefficient of molar substitution of A in complex and ranges from 1.0 to approximately 1000; O and O', independently, denote covalent bond or spacer compound connecting Y, P, and A by covalent linkages. EFFECT: improved oral supply of pharmaceutics. 38 cl, 6 ex |