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filingDate 1994-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1999-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2139349-C1
titleOfInvention Method of effective production of 7-aminodeacetoxycephalosporanic acid through 2-(carboxyethylthio)-acetyl-7-amino- -deacetoxycephalosporanic acid and 3-(carboxymethylthio)- -propionyl-7-aminodeacetoxycephalosporanic acid
abstract FIELD: biotechnology, antibiotics. SUBSTANCE: invention presents the completed effective process of producing and isolation of 7-aminodeacetoxycephalosporanic acid through 2-(carboxyethyl- -thio)-acetyl- and 3-(carboxymethylthio)-propionyl-7-amino- -deacetoxycephalosporanic acid using the transformant strain of Penicillium chrysogenum expressing expandase in combination with acyltransferase. Method involves the use of 3-carboxy- -methylthiopropionic acid as a precursor of by-side chain of the end product. 7-Aminodeacetoxycephalosporanic acid is an intermediate compound used for production of cephalosporins. EFFECT: increased yield of strains. 5 cl, 8 dwg, 2 tbl, 5 ex
priorityDate 1993-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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