| abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to a new compound of the general formula (I) and its pharmaceutically acceptable salts and a method of synthesis of these derivatives and a pharmaceutical composition showing an antiviral activity and containing these derivatives as an active component where R 1 ,R 2 and R 3 mean independently hydrogen, halogen atom, C 1 -C 5 -alkyl; Z means oxygen, sulfur atom and carbonyl group; X means oxygen atom; n = 1-2 and (sub)cycloalk(en)yl means: or where means or where R 4 and R 5 mean independently hydrogen atom, hydroxymethyl, hydroxymethyl protected by the substituted silyl-group. EFFECT: new nucleoside derivatives, antiviral activity, improved method of synthesis. 4 cl, 1 tbl, 55 ex |