| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_977ebb660999f345084ffad260515ff6 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/F23C5-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B53-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D221-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/F23C5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-147
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate |
1994-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1999-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39afb7ff18eff47f452de10d3b2c53e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c4f7892e8d3485b496c6fd43a25d83b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9447cdf39ce22adc3e6c6be3a91492fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a55c7df6bf05d1eb34f21039d9db62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6c475f248e368b6e034942fa9802abf |
| publicationDate |
1999-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2137774-C1 |
| titleOfInvention |
Method of preparing 9-aminocamptotecine and sulfonyloxy-derivatives of 9-nitro-20(s)- camptotecine |
| abstract |
FIELD: organic synthesis. SUBSTANCE: 9- aminocamptotecine with formula I (presented in description) is prepared by reaction of compound depicted by formula III, wherein hydroxy group of ring A is located in position 10 or 12, with nitration agent to form corresponding compound IV. The latter is further converted into compound V in which XO is a group replaceable upon hydrogenation. Next step of reaction consists in reductive removal of group XO and simultaneous reduction of nitro group in compound V to give final product (I). Compounds of formulas V and VII exhibit antitumor activity. EFFECT: simplified process and reduced expenses. 15 cl, 21 ex |
| priorityDate |
1993-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |