| abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to a compound of the formula (I) where stereocenter α has R- or S-configuration or it is racemic; r - a whole number from 0 to 5; R 1 , R 2 - hydrogen atom, alkyl; or R 1 and R 2 in common with nitrogen atom to which R 1 is bound and carbon atom to which R 2 is bound form 3-10-membered monocyclic saturated ring system involving nitrogen atom, 1-8 carbon atoms and one heteroatom of the formula =N-V-R 1 where V is absent or means COO- or = N-COO-benzyl or = N-CH 2 -pyridyl; R 3 - H, C 1-4 -alkyl, C 2-10 -cycloalkyl, C 6-10 -nonsubstituted aryl and pyridyl; R 4 is C 1-5 -alkyl. Compounds are synthesized by interaction of the compound of the formula (II) and formula (III) in the presence of a strong base at low temperature. The method shows high degree of diastereoselectivity, does not use toxic reagents. EFFECT: decreased time of synthesis. 29 cl, 19 ex |