http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2133745-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_56ee5285e8e8edccb061046ff20da7a6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37 |
| filingDate | 1994-07-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2a49930c98475678fdfa47fcf916a36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_155342044ebde359276d6d69de6457ed http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4bec487261a1ae1f8f9cce8b71ab6fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67b100d651f668148ea101f04ee9189e |
| publicationDate | 1999-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2133745-C1 |
| titleOfInvention | Coumarin derivatives, use thereof as pla2 inhibitors, and drug |
| abstract | FIELD: medicine, more particularly use of coumaring and carbostyrenes as PLA 2 inhibitors. SUBSTANCE: described are new coumarin derivatives, method of preparation thereof and drugs containing said compounds, described are coumarin and carbostyryl derivatives of general formula I wherein R 1 is hydrogen or C 1 -C 6 alkyl; R 2 is hydrogen or residue OT 1 ; R 3 is hydrogen or residue OT 2 ; R 4 is hydrogen or C 1 -C 6 alkyl; T 1 and T 2 are identical or different, and each is hydrogen, C 1 -C 6 alkyl C 1 -C 6 alkanoyl, or T 1 and T 2 combined with atoms to which they are attached, form 5-7 membered heterocyclic ring which is substituted, if desired, by oxo or thioxo; or Q is oxygen atom, X is sulfur atom or NH group or Y valent group, C 1 -C 6 alkylene residue which is, if desired, substituted by hydroxy group or amino group; phenylene residue which is if desired mono- or multiple substituted by hydroxyl, halogen, C 1 -C 6 alkyl or carboxyl; Z is hydrogen, halogen, carboxyl, hydroxymethyl, C 1 -C 6 alkoxycarbonyl, cyano or WR 5 R 6 ; R 5 and R 6 are identical or different and each is hydrogen or C 1 -C 6 alkyl, or R 5 and R 6 combined with nitrogen atom to which they are attached, form 3-7 membered heterocyclic ring which is substituted by oxo, hydroxy or C 1 -C 6 alkoxy group, tautomers thereof and also salts thereof with non- toxic acids or bases. Also described is method of preparation thereof and also drug based on compounds of formula I having PLA 2 -inhibiting activity. EFFECT: improved properties of the drug. 6 cl, 14 ex, 1 tbl |
| priorityDate | 1993-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 154.