| abstract |
FIELD: organic chemistry, drugs. SUBSTANCE: invention relates to carbocyclic and heterocyclic condensed compounds of quinoline carboxylic acid of the general formulas (1) , (2) , (3) and (4) or their pharmaceutically acceptable salts where R 1 , R 2 - H, F, Cl, Br, CF 3 or C 1-4 -alkyl; R 3 - unsubstituted phenyl, phenoxy-, phenylthio-, phenylsulfinyl-group, phenyl-N(R 4 )-, furyl, thienyl, pyridyl, thiazolyl or oxazolyl or substituted with 1-2 F, Cl, Br, CF 3 or C 1-4 -alkyl, alkoxy-, alkylthio- or alkylsulfinyl-group (values of other radicals are given in p. 1 of the invention claim). Compounds (1-4) are immunodepressants or immunomodulators and can be used for treatment or prophylaxis of transplanted organs rejection in mammals. EFFECT: valuable properties of compounds. 13 cl, 5 tbl, 208 ex |