| abstract |
FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R 1 is C 1-7 -alkyl; R 2 is C 1-4 -alkyl; X is C 1-5 -alkyl; R 3 is a lower alkyl; B - is C 1-5 -alkyl; D is C 1-5 -alkoxy; M - phenylalanine; R 4 - H; R 5 - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex |