| abstract |
FIELD: pharmaceutical medicine. SUBSTANCE: hard dozed form includes porous reticulate structure of matrix material rapidly dispersing in water. Form is made from solution containing 0.1 to 15 wt % of matrix-forming agent. The latter is selected from the group including gelatin, pectin, soya been fiber protein, and their mixtures, and also containing one or several amino acids with 2 to 12 carbon atoms (glycine, L-aspartic acid, L-glutamic acid, L-hydroxyproline, L-isoleucine, L-leucine, and L-phenylalanine) . Form is prepared by lyophilization of indicated matrix agent solution. Weight ratio of high- molecular components to amino acid ranges from 10:1 to 1:5. Form can be completed with active ingredient in the form of coated particles, coating agent being a fatty acid, glyceride, triglyceride, or their mixture. EFFECT: improved dispersing ability in water (less than in 10 s) and increased strength. 15 cl, 2 tbl, 7 ex |