| abstract |
FIELD: organic chemistry, antibiotics. SUBSTANCE: invention describes a method of synthesis of the carbapenem intermediate compound of the formula (VI) where R means: (a) hydrogen atom; (b) methyl or (c) hydroxy-protective group and P′ means nitrogenous protective group; Nu means nucleophilic group taken from -CH 2 CO 2 --t-Bu and -SR 2 where R 2 means hydrogen atom, direct or branched C 1 -C 10 -lower alkyl, direct or branched C 2 -C 10 -alkenyl and alkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -cycloalkyl-C 1 -C 10 -alkyl, C 1 -C 6 -alkyl-C 3 -C 6 -cycloalkyl, aryl and aralkyl. Method of synthesis involves the interaction reaction of compound of the formula (V) where R, P′ and Nu are indicated above with weak acid in ether or ester solvent. EFFECT: universality of method of synthesis of the end compounds. 8 cl, 3 dwg, 5 ex |