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filingDate 1994-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1999-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b02188806e324c320269dd44f94cc0e5
publicationDate 1999-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2130460-C1
titleOfInvention Derivatives of tetrahydropyrane and pharmaceutical composition
abstract FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new compounds of the formula (I) where R 1 means a group of the formula (1a) or (1b) where R 7 means optionally substituted hydroxy-group, acyloxy-group, halogen atom, -OR 10 where R 10 means lower alkyl optionally substituted with -O(CH 2 ) m OH where m is a number from 2 to 4 or -OCONH 2 ; R 7a means hydrogen atom; or R 7 and R 7a mean oxo-group; R 8 means hydroxy- or methoxy-group and R 9 means hydroxy- or acyloxy-group; R 2 means hydrogen atom, acyloxy- -group or optionally substituted hydroxy-group; between two carbon atoms bound with dotted line - a simple or double bond exists; R 3 means methyl, ethyl, n-propyl or allyl; or R 4 means hydrogen atom or hydroxy-group and R 4a means hydrogen atom; or R 4 and R 4a mean oxo-group; or R 5 means hydroxy-group and R 5a means hydrogen atom; or R 5 and R 5a/ mean oxo-group; A means a group of the formula -CH(OR 6 )-CH 2 -(CH 2 ) n or -CH= CH-(CH 2 ) n - bound with carbon atom through (CH 2 ) n -; R 6 means lower alkyl and n = 1 or 2. Compounds can be in free form or as salts. These compounds are used as pharmaceutical preparations, especially as anti-inflammatory and antiprofilerative agents. EFFECT: enhanced effectiveness of compounds as curative agents. 9 cl, 4 tbl, 36 ex
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2543721-C2
priorityDate 1993-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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