| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to spirocompounds of the general formula (I) , their pharmaceutically salts, enantiomers, racemates and quaternary compounds that are derivatives of the indicated compounds containing tertiary nitrogen atom. Compounds have five-membered group where spiro-bond is realized by carbon atom which is a component both five-membered group and a saturated ring system. Saturated ring system has one nitrogen atom and a ring system A has a residue of the formulas (a) , (b) , (c) . In structure (a) a bridge is bound to position 1 by one end and to position 4 or 5 - by the other end; m = 2; n and p = 1 being n + p = 2; R 1 - H, C 1-6 -alkyl, C 2-6 -alkynyl, the indicated five-membered residue 3-ethylhydantoin, 1-acetylhydantoin, 3-methylhydantoin and the others indicated in p. 1 of the invention claims. Compounds of the formula (I) show activity with respect to central and peripheral nervous system, in part, agonistic activity to muscarine. EFFECT: improved method of synthesis, activity with respect to nervous system. 10 cl, 1 dwg, 3 tbl, 61 ex |