| abstract |
FIELD: pharmaceutical industry. SUBSTANCE: invention describes new pyrimidine derivatives of formula (I-1) and (I-2) wherein R 1 and R 5 are identical or different and are independently hydrogen or C 1 -C 3 alkyl group, or taken together, form cyclopentyl or cyclohexyl ring; A is group of formula II: wherein R 1 and R 2 are independently hydrogen or C 1 -C 3 alkyl group, and R 3 is hydrogen, C 1 -C 3 alkyl group or halogen, and B is 1- (substituted)-1,2,3,4-tetrahydroisoquinolin-2-yl of formula (III-1) or 7-substituted)-4,5,6,7- tetrahydrothieno (2,3-cie)-pyridin-6-yl of formula (III-2), wherein R 6 is hydrogen or C 1 -C 3 alkyl group, and pharmaceutically acceptable salts thereof which have superior antisecretory activity with respect to pharmaceutical compositions which comprise active ingredient. Present invention also describes new intermediate compounds and methods of preparing thereof. EFFECT: improved properties of the title compounds. 83 ex, 3 tbl |