| abstract |
FIELD: medicine, pharmacology. SUBSTANCE: invention proposes an agent for inhibition of neurotoxicity caused by β--amyloid peptides. This agent is a compound of the general formula (I) early known as an antiestrogen: where R 1 and R 2 mean independently each of other hydrogen atom, -CH 3 , -alkyl) or -Ar where Ar is optionally substituted phenyl; R 2 is taken from a group consisting of pyrrolidine- and piperidine-group, or its pharmaceutically acceptable salt or solvate. EFFECT: broadened pattern of an agents for indicated prescription. 2 cl, 3 ex |