| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes compounds of the general formula (I) where heteroatom X means oxygen but can be another; group W means preferably carbonyl-group but can has another values. Preferable heterocyclic ring is 4-oxo-4H-1-benzopyrane and it can has broad pattern of substituents R 2 , R 3 , R 6 and R 7 ; Y means a bound group taken from the broad pattern but involving -COO, -CONH, -O-, -SO 2 and SO 2 NH-; Z means alkylene chain and B - a complex amine. These compounds and their prodrugs, enantiomers and diastereoisomers, N-oxides and pharmaceutically acceptable salts are benefit for treatment of patients with hypertension and urinary tract disorders associated with benignity prostate hypertrophy and other sicknesses. Invention proposes a method of synthesis of compounds of the formula (I) that involves condensation of compound of the general formula (II): F 1 -Y-Z-L where F 1 means formula (III) where , X, W, R 2 , R 3 , R 6 and R 7 have values indicated above; L - halogen atom or a group to be split with compound of the formula (IV): H-B where B has values indicated in point 1 of invention claim. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 16 cl, 16 dwg, 2 tbl, 130 ex |