http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2127739-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-0015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J3-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J3-00 |
| filingDate | 1994-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e92bd2fffc2dcdb22d44d738c0f7091e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28a5aa411b814d55320d63a1c5c254c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_164ffdfaa6c8b7a72add847deb2b580d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_128b9762c106fddaf052e9a990a064c0 |
| publicationDate | 1999-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2127739-C1 |
| titleOfInvention | PROCESS FOR PREPARING 6α,9α-DIFLUORINATED STEROIDS AND INTERMEDIATE COMPOUNDS |
| abstract | FIELD: medicine. SUBSTANCE: invention describes new process for preparing 6α,9α-difluorinated steroids of formula I: 6α,9α wherein R is hydrogen atom or ester residue. The process comprises treating compound of formula II: with oxidative destructing agent to give compound of formula III: wherein functional ketone group in position 3 is protected in the form of enol ether or ester, and functional acid group is optionally protected in position in the form of ester to give compound of formula IV: 17β, wherein R is as defined above, and is ether or ester enol residue which is treated with electrophilic fluorinating agent to give compound of formula V: R 1 , compound is treated with nucleophilic fluorinating agent to give compound of formula I which is, when R is ester residue, optionally saponified to give corresponding acid. The process is advantageous in that only functional ketone group is protected in position 3 in the form of enol ether or ester to give compound of formula IV. The invention also describes new compounds of formula VI: wherein R is as defined in formula I, X is hydrogen or fluorine atom, and Y bonded with dotted lines is essentially system of 3-keto , or X is hydrogen atom, and Y bonded with dotted lines is essentially system of Δ4 in which 3-OR 1 Δ3,5 is as defined in formula I. Compounds are useful as intermediate compounds for preparing steroidal drugs. EFFECT: more efficient preparation process. 10 cl, 4 ex |
| priorityDate | 1993-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.