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publicationDate 1999-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2127732-C1
titleOfInvention Bis-phenylpiperazine nicotinic acid esters, method of their synthesis (variants), pharmaceutical composition, method of treatment of patients with central nervous system disorders
abstract FIELD: organic chemistry, medicine. SUBSTANCE: invention describes new compounds of the formula (I) where R is taken from saturated alkyls, cycloalkyls, or a group of the formula (II) where G means CH or nitrogen; m = 0-4; R,R 2 and R 3 are similar or distinct and taken from hydrogen, halide atoms, C 1 -C 5 -alkyl, cyano-, nitro-group, -CO-NH 2 , or its pharmacologically active salt. New compounds can be used for treatment of patients with central nervous system disorders. Invention describes also a method for synthesis of the above indicated compounds, a pharmaceutical composition based on compound of the formula (I) and a method of treatment of patients with central nervous system disorders using compound of the formula (I). EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 10 cl, 1 tbl, 5 ex
priorityDate 1992-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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