| abstract |
FIELD: organic chemistry, pharmacology. SUBSTANCE: invention relates to nitroesters of the general formula (I) where A and B - hydrogen atom, free or substituted alkyl; R - a residue of the formula (a) , (b) , (c) , (d) , (e) , (f) , (g) , (h) , (i) , (j) ; R 2 - hydrogen atom, methyl, ethyl, C 3-12 -alkyl; Y - oxygen atom, NH, NR 1 where R 1 - alkyl; n = 1-10 that show antiinflammatory and/or antithrombocyte activity. Introduction of terminal nitroester group into general formula of derivatives (I) enhances pharmacological activity of nonsteroid antiinflammatory agents and eliminates adverse effects caused by treatment of these drugs. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 10 cl, 1 tbl, 4 ex |