http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2127259-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-404 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-403 |
| filingDate | 1994-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1999-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_173c74a62a227067d592dab90cdf277a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7434b9c17c9d48be26c9787c483a7b01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ac7f22031f2c2ca994750634f9f0df1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d938424bc7598cf1b993a2086372349 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8261419c03d4c5f6e50a1b1edd9c5858 |
| publicationDate | 1999-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2127259-C1 |
| titleOfInvention | Derivatives of sulfonylurea or their pharmaceutically acceptable salts, a method of their synthesis and a pharmaceutical composition based on derivatives of sulfonylurea showing antitumor activity |
| abstract | FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of sulfonylurea of the formula: A-S(O) 2 -NH-C(O)-NH-Ph(R 2 )(R 3 ), where A - 2,3-dihydro-1H-indolyl or IR 1 -indolyl; R 1 is C 1 -C 6 -alkyl; R 2 and R 3 mean independently each of other - H, halogen, C 1 -C 6 - alkyl, trifluoromethyl at condition that only one of substituents R 2 and R 3 can be hydrogen. These derivatives are used in a pharmaceutical composition showing antitumor activity. Compounds are synthesized by interaction of compound Y-Ph(R 2 )(R 3 ) with sulfonyl compound of the formula: A-S(O) 2 -X where Y is NH 2 or NCO; X is NCO, NH 2 or NHCOO-R a where R a is C 1 -C 3 -alkyl at condition that if X means NCO or NHCOO-R a then Y is NH 2 ; if X is NH 2 then Y is NCO. EFFECT: improved method of synthesis, enhanced antitumor effectiveness of compounds. 8 cl, 1 tbl, 7 ex |
| priorityDate | 1993-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.