| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention proposes a new agent and a pharmaceutical composition based on thereof for treatment of patients with irritable bowel syndrome. Agent is derivatives of isoxazole: 2-(di-n-propyl- -amino)-8-(isoxazole-5-yl)-1,2,3,4-tetrahydronaphthalene; S- -(-)-2-(di-n-propylamino)-8-(isoxazole-5-yl)-1,2,3,4-tetrahydro-naphthalene, R-(+)-2-(di-n-propylamino)-8-(isoxazole-5-yl)-1,2,3,4-tetrahydronaphthalene, 2-(di-n-propylamino)-8-(3-bromoisoxazole-5-yl)-1,2,3,4-tetrahydronaphthalene, 2-(di-n-propylamino)-8-(4-methylisoxazole-5-yl)-1,2,3,4-tetrahydro-naphthalene, 2-(di-n-propylamino)-8-(3-methylthioisoxazole-5-yl)-1,2,3,4-tetrahydronaphthalene, 2-(di-n-propylamino)-8-(3-methylisoxazole-5-yl)-1,2,3,4-tetrahydronaphthalene, 2-(di-n-propylamino)-8-(4-methoxyisoxazole-5-yl)-1,2,3,4--tetrahydronaphthalene, or their pharmaceutically acceptable salts or solvates. EFFECT: broadened pattern of agents for treatment. 3 cl, 2 tbl, 4 ex |