| abstract |
FIELD: organic synthesis. SUBSTANCE: new heterocycles with general formula I: is provided, wherein X is carbimino group substituted by cyano group at nitrogen atom, carbonyl, or sulfonyl; Y ethylene, trimethylene, ethenylene, methylenecarbonyl or carbonylmethylene, all unsubstituted or substituted by a couple of groups R C -R D or R C -R D , and also unsubstituted carbonylimino, iminocarbonyl, methylideneimino, or iminomethylidene groups; one of R a -R D groups signifies A-B group, in which A is group , , or (meanings of other radicals are presented in claim 1 of invention formula). Compounds I have antiinflammatory and bone-degradation inhibition activities and also exhibit antithrombogenic, antiaggregation, antineoplasmic, and antimetastatic effects. EFFECT: extended pharmaceutical possibilities. 6 cl, 2 tbl, 40 ex |