| abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to diazabicyclic compounds of the formula (I) where R 1 - phenyl; R 2 - hydrogen; A - phenyl substituted with alkoxy-group; m and n = 0, 1 or 2; R 3 , R 4 , R 5 , R 6 and R 7 - hydrogen; G means a group (-CR 8 R 9 ) p ; p = 1-3; R 8 and R 9 - hydrogen, or their pharmaceutically acceptable salts. Compounds of the formula (I) and a pharmaceutical composition based on thereof are antagonists of receptors of P-substance and can be used for treatment and prophylaxis of patients with inflammatory sicknesses, fear, depression or dysthymia, enuresis. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 8 cl, 2 ex |