| abstract |
FIELD: medicine, sorbents. SUBSTANCE: affine sorbent has a carrier containing an immobilized human α 2 --macroglobulin. Method of a sorbent preparing involves immobilization of human α 2 --macroglobulin at pH 7.0-8.2 followed by its treatment with thio-ester loop modifying agent. The latter is monomethylamine hydrochloride or proteolytic enzyme plasmin of human blood plasma. Invention can be used for development of new approaches to treatment of patients with sicknesses caused by massive inflow of cytokines in blood, for example, as a result of septic shock. EFFECT: improved method of sorbent preparing, enhanced effectiveness of sorbent. 4 cl, 4 ex |