| abstract |
FIELD: organic chemistry, pharmacology. SUBSTANCE: invention relates to oxides of 4-phenylpiperazines and 4-phenylpiperidines of the general formula (I) where R 1 is C 1-8 -alkoxy; R 2 is hydrogen or methyl; A is N, CH or N + -O - ; B means N or N + -O - at condition that when A means N or CH then B must be N, or their pharmaceutically acceptable salts. The synthesized compounds show significant activity in mammals and neuroleptic and antipsychotic effect in human. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 20 cl, 1 tbl, 3 ex, 7 dwg |