| abstract |
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of oxime of the formula (I) where R 1 is H, C 1-6 -alkyl; R 2 is C 2-6 -alkylene; X is an nonsubstituted C 6-10 -aryl or that substituted with one substitute taken from a group involving C 1-6 -alkyl, OH, acylhydroxy-group, C 1-4 -alkoxy-group, halogen atoms, phenyl, phenylthio-group, phenylsulfonyl-group, phenylsulfonylamino-groups, pyridylsulfonyl-groups, imidazolyl- and pyridyl-groups or heteroaromatic group: pyridyl, quinolyl and imidazolyl; y is O, S or -H; Z means a group of the formula (Za) , (Zb) , (Zc) or (Zd) . Compounds (I) can be used for treatment and prophylaxis of patients with hyperlipidemia, hyperglycaemia and obesity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 27 cl, 27 tbl, 57 ex |