http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2122541-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4acae202b6a15394281949545e70d2f6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-92 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 1993-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e03e19a3c1f2c61ffb7a16cd83031d1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfe6791df58ec9cb55ca379c13b49f39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3353810dda7ad97e1be6a0d8d0dcc61 |
| publicationDate | 1998-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2122541-C1 |
| titleOfInvention | Method of synthesis of sulfur-containing imidazole derivatives, intermediate compounds |
| abstract | FIELD: organic chemistry and technology. SUBSTANCE: invention relates to a new method of synthesis of sulfur-containing derivatives of imidazole of the general formula (I) and intermediate compounds of the formulas (III), (IV) and (V) where R 1 -C 1-4 is alkyl; R 2 - is alkylthionyl containing 1-4 carbon atoms and possibly substituted with one or some substituents taken from halogen, hydroxyl, alkoxy, benzyloxy and means phenylthio or mercapto; R 3 is free carboxyl or salt or ester with linear or branched C 1 -C 4 -alkyl, or hydroxyalkyl; R 4 is a radical (CH 2 ) m -SO 2 -X-R 10 where X is NH, NHCONH-, NHCO-O; R 10 is hydrogen or C 1 -C 3 -alkyl; m = 0, 1. Synthesis is carried out by interaction of imidazole of the formula (II) with the corresponding halogen-derivative - a compound of the formula (III) where B - boron atom; X 1 and X 2 - hydroxyl or X 1 with X 2 form together with boron atom with which they bound to cycle to compound of the formula (IV). The latter is subjected for interaction with a compound of the formula (V) where X 4 is halogen atom. Compounds of the formula (I) or their salts can be used as agents for treatment of patients with arterial hypertension, cardiac and renal failure and for prevention of angioplasty stenosis relapse. EFFECT: improved method of synthesis, new valuable pharmacological properties of compounds. 7 cl, 11 ex + |
| priorityDate | 1993-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 214.