abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of arylhydroxycycloalkenyl- and arylhydroxyiminocycloalkenylhydroxyureas. The proposed compounds inhibit activity of enzyme 5-lipoxygenase and can be benefit for prophylaxis, treatment or relief of sicknesses course associated with inflammatory processes, for example, gut inflammatory and rheumatic arthritis, allergia and cardiovascular diseases in mammal subject, for example, in human. Invention relates to also pharmaceutical compositions containing these compounds. EFFECT: enhanced effectiveness of compounds proposed. |