| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37555e87c88017b74fba94c8b8abbb42 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D305-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 |
| filingDate |
1993-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1998-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b008444d365b9fe7278b824557a7c6d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_271fe77377af411498f3580f8a35c0e6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c82d6000d4bae4a03d7ab7225f84ca3 |
| publicationDate |
1998-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2118958-C1 |
| titleOfInvention |
Method of synthesis of taxane derivatives and intermediate compounds of synthesis |
| abstract |
FIELD: organic chemistry. SUBSTANCE: invention relates to a method of synthesis of derivatives of taxanes of the general formula (I) by esterification of the protected baccatine (III) or protected 10-deacetylbaccatine (III) with acid of the general formula (II) . In general formulas (I) and (II) Ar means phenyl; R 1 and R 2 have similar or different values and mean hydrogen atom, C 1 -C 8 -alkyl, C 1 -C 8 -alkoxyphenyl; R 3 means acetyl or protective group of functional hydroxy-group and R 4 means protective group of functional hydroxy-group; R means phenyl or radical of the formula R 5 --O- where R 5 means direct or branched C 1 -C 8 -alkyl. Compounds of the general formula (I) can be used for preparing taxol, taxoter and their analogs that show the apparent antitumor activity. EFFECT: improved method of synthesis. 16 cl, 5 ex |
| priorityDate |
1992-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |