| abstract |
FIELD: organic technology; pharmacology. SUBSTANCE: derivative of ergoline having formula I wherein R 1 -C 2 H 5 ,R 2 -(CH 2 ) 3 N(CH 3 ) 2 ,, R 3 is allyl, R 4 =R 5 =H is prepared by interaction of ergoline amide having formula II with 1-4 equivalents of isocyanate having formula III . In formulae II and III R 1 ,R 2 ,R 3 ,R 4 and R 5 are as mentioned above; interaction is carried out in 1,1-dichloroethane or in toluene at 35-60 C in the presence of CuCl and in the presence of phosphorous compound chosen of PPh 3 ,P(pClPh) 3 ,P(pMePh) 3 and MePh 2 P. Compounds having formula I are suitable as antiprolactinic and antiparcinsonic agents. EFFECT: improved efficiency of the method. |