| abstract |
FIELD: organic chemistry. SUBSTANCE: products: derivatives of sulfonamide of the formula (I): where R - six-membered heterocycle with nitrogen atom or NR 6 R 7 ; R 6 - - hydrogen; R 7 - hydrogen or group of the formula ; R 2 =R 3 is H; m = 4-6; n = 1; p = 0 or 1; R 4 is -C 1-10 -alkyl, benzyl, styryl, phenyl, thienyl or substituted naphthyl; R 5 is COOR 11 ; R 11 is H or methyl that are antagonists of IIb/IIIa-receptors of fibrinogen and inhibit platelet aggregation and benefit for prophylaxis and treatment of diseases caused by thromb formation. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 5 tbl |