| abstract |
FIELD: chemistry of heterocyclic compounds, more particularly, medicine. SUBSTANCE: present invention describes novel N-(hetero) aryl-N-(hetero)-tetralinealkyl piperazines having serotoninergic, dopaminergic and adrenergic activities of general formula I: wherein Ar 1 is phenyl or thienyl condensed with 5 or 6-membered carbocyclic ring; R 1 and R 2 are independently H or C 1-5 alkoxy; Ar 2 - is phenyl unsubstituted or substituted by methoxy, halogen, trifluoromethyl, or pyridyl; is selected from wherein n is 1 or 2; m is 2 or 3, and pharmaceutically acceptable salts thereof. The claimed methods make it possible to prepare the desired product derived from compound of formula (I): and corresponding piperazine containing reagent. EFFECT: improved properties of the title compound. 10 cl, 3 tbl |