http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2113437-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 1992-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1998-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc8ab035890120f94268995591208cab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_025908a1777030869972e1e91e38a8de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9edfb0133dd7a720ad922d6a76fcb7c0 |
| publicationDate | 1998-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2113437-C1 |
| titleOfInvention | Substituted pyrimidines or their pharmaceutically acceptable salts, or n-oxides, methods of their synthesis and pharmaceutical composition based on thereof |
| abstract | FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: products: substituted pyrimidines of the formula (I) where R 1 ,R 2 ,R 3 and R 4 - H, C 1 -C 6 -alkyl, C 1 -C 6 -perfluoroalkyl; R 5 - H or if n = 1 then R 5 together with R 3 forms double bond; n = 0-1; p = 0-2; m = 0-3; Ar 1 and Ar 2 - substituted phenylene, pyridine. Reagent 1: pyrimidine of the formula (II) where R 1 ,R 2 ,R 3 ,R 4 ,R 5 , n and p have values indicated above; Z 1 - split off group; R 7 - lower alkyl. Reagent 2: amine of the formula H 2 N-(CH 2 ) m -Ar 1 -Ar 2 where m, Ar 1 and Ar 2 have above indicated values. Reaction conditions: in the presence of inorganic or organic base. Synthesized compounds are used in medicine as antagonists of angiotensin-II. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2478637-C2 |
| priorityDate | 1991-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 226.