| abstract |
FIELD: organic chemistry; medicine. SUBSTANCE: novel commercial products having structure which is analog to those of 15-desoxypergyaline with formula I (where A is single bond, -CH 2 - group, -CH 2 O- group, -CH 2 NH- group, CH(OH)- group, CHF- group or -OH(OCH 3 ) group; n is 6 or 8) and additive salts thereof are proposed. Compounds having formula I are prepared of compounds having formula II , protective groups being removed. To prepare compound having formula II acid and amine are affected by condensation, or amine interacts with carbonate. Compound having formula I is proposed as active ingredient for pharmaceutical composition which possesses immunodepressive activity. EFFECT: improved quality of desired product, improved efficiency of the method. 13 cl, 1 tbl |