| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d709e3167fa2f99a1803c9cfeb0aca63 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D451-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D451-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-79 |
| filingDate |
1991-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1997-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86f4597775b6bfffd880fd5668c3a6c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e16d87891b014a4b6861765a2fe83593
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0d5285652c76017e3ea22e593d7f1e5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aabee245419bd683ca9f0c5882abc10f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05c87843cc41455d4f1841b85dc09c59 |
| publicationDate |
1997-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2098415-C1 |
| titleOfInvention |
Method of synthesis of the substituted benzofuran derivatives or their pharmaceutically acceptable salts |
| abstract |
FIELD: organic chemistry. SUBSTANCE: product: derivatives of the substituted benzofuran of the formula (I): where one of substituents R 1 and R 2 means hydrogen or halogen atom and other means independently of the first one amino-group or C 2 -C 4 -alkanoylamino-group; R 3 means hydrogen atom, direct or branched C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-group or C 2 -C 4 -alkoxycarbonyl-group, halogen atom or phenyl or phenyl substituted with C 1 -C 4 -alkyl group; A means group -(CH 2 ) n -Het where Het means possibly the substituted heteromonocycle or heterobicycle containing one or two nitrogen atoms; n = 0 or whole numbers 1-3; symbol means a single or double bond. Compounds can be synthesized by a method that involves interaction of compound of the formula (II): where substituent L means a removing off group; substituent R 4 means hydrogen atom or carboxyl-protecting group with a compound of the formula (III): R ′ 3 - C ≡ C - R ′ 3 leading to formation of compound of the formula (IV) which then is cyclized to compound of the formula (V): . The latter is interacted with compound of the formula (VI): H 2 N-A. EFFECT: improved method of synthesis. |
| priorityDate |
1990-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |