http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2097384-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa1a07405400414d62a847fead2b8170 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1990-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b086e0a2ae57ad377e049ef4bc36b76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3eeeb2e3a4f0d5039c900aba1bcf6a26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce6520dc346f84e13f1818397f5b2d8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af15d6d69d2483774ddbd36a9e776ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_220329944f790e2bad52e7500a78a5f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13f45f93288a53e05c133a9c754c1e71 |
| publicationDate | 1997-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2097384-C1 |
| titleOfInvention | Derivatives of amino-7-(chr2r3)-3h,5h-pyrrolo-[3,2-d]-pyrimidine-4-one, methods of their synthesis and a method of selective inhibition of mammalian t-lymphocytes proliferation and no effecting on chr2r3-lymphocytes |
| abstract | FIELD: organic chemistry. SUBSTANCE: invention proposes derivatives of 2-amino-7-(CHR 2 R 3 )-3H, 5H-pyrrolo-[3,2-d] -pyrimidine-4-one of the formula: where: R 1 - H, NH 2 ; R 2 - saturated 5-membered heterocycle containing S or O as heteroatom, or 6-membered N-containing heterocycle that can be substituted; R 3 - H, CH 2 , CH 2 CO 2 H, CH 2 CONH 2 , CO 2 CH 3 , CO 2 H or CH 2 CH 2 OH,, or R 2 and R 3 together with CH form cyclohexyl- or cyclohexenyl-group. The synthesized compounds are inhibitors of purine-nucleoside phosphorylase. Invention proposes methods of their synthesis and a method of selective inhibition of mammalian T-lymphocytes proliferation but no effecting on B-lymphocytes. EFFECT: improved method of synthesis. 10 cl, 1 tbl |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2672249-C9 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2672249-C1 |
| priorityDate | 1989-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 509.