| abstract |
FIELD: pharmaceutical industry. SUBSTANCE: present invention describes use of compound as drug having formula: or pharmaceutically acceptable acid addition salt thereof or stereochemical isomeric form thereof in which R 1 and R 2 each is independently hydrogen, C 1-6 alkyl or C 3-6 cycloalkyl; or R 1 and R 2 together which nitrogen atom to which said R 1 and R 2 are attached form pyrrolidinyl, piperidinyl, morpholinyl, piperazinyl or C 1-4 alkyl piperazinyl; X is oxygen or sulfur; R 3 is hydrogen or C 1-6 alkyl; R 4 , R 5 и R 6 are each independently hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, nitro, trifluoromethyl, cyano, aminomethyl, cyano, aminomethyl, carboxy, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonyl, aminocarbonyl or hydroxy; R 7 is hydrogen or halogen; and R 8 , R 9 and R 10 are each independently hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, nitro, hydroxy, trifluoromethoxy, 2,2,2- trifluoroethoxy (trifluoromethyl) carbonyl, aminocarbonyl (cyclopropyl) carbonyl or C 1-6 alkyl-(0=Y)-in which Y represents =O, =H, -OH, N-OCH 3 , N-NH 2 or N-N(CH 3 ) 2 provided that R 1 is other than n-propyl when R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 and R 10 are hydrogen, R 8 is 4-ethoxy and X is oxygen, and X is other than sulfur when R 1 , R 2 , R 3 , R 6 , R 7 , R 8 , R 9 and R 10 are hydrogen, and R 4 and R 5 are 3,4 dimethoxy group. EFFECT: improved properties of the pharmaceutical composition. 15 cl, 3 tbl |