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assignee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51f318518efb5cac5b61814366cdf2d0
classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-36
filingDate 1991-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1997-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7fdc1034c252a9f0369ae5911d56a336
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6009a3a1a2673ecb7508408e911414b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6f9f2b17db8c7acb27000903c379253
publicationDate 1997-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2085209-C1
titleOfInvention Method of protamine preparing
abstract FIELD: medicine. SUBSTANCE: method involves removing fat and connective tissue from milt of fish, homogenization, filtration, centrifugation, precipitate washing with Ringer solution, ultrasonic oscillation treatment. The obtained solution is purified by ion-exchange chromatography, treatment with acetic anhydride at ratio protamine : acetic anhydride = (1:100)-(1:300) followed by isolation of the end product by chromatography. The obtained product is used for heparin inactivation. EFFECT: increased antiheparinic activity. 1 dwg
priorityDate 1991-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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