http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2081124-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7e28fd0650da9b80caae1448f9f9ab5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F226-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-79 |
| filingDate | 1993-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1997-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05b44fcc31611d4b4aedee1e9ac3e8d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3f9761c584be290b4632b7e7dc8089a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d6d6dbebdd64bb20b0fef5182f8e38a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e02c49d0f35ac0e9bf4b3cf72124ae0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ab14856d9aa9393c7a0630f12705d0d |
| publicationDate | 1997-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2081124-C1 |
| titleOfInvention | Water soluble copolymers of n-vinyl-2-pyrrolidone and crotonic acid derivatives having glucocorticoid activity and process for preparation said copolymers |
| abstract | FIELD: chemistry of high-molecular weight compounds, in particular, medicine and bioorganic chemistry, and more specifically, water soluble copolymers. SUBSTANCE: invention describes water soluble copolymers of general formula , where R 1 is H or -CH 2 CH 2 N(C 2 H 5 ) 2 ;; R 2 is corticosteroid residue adjoined to 21-CH 2 OH- group consisting of hydrocortisone and dexametasone where n is 56.4-89.8 mole%, m is 2.0-29.8 mole%, l is 5.5-13.8 mole% with molecular weight of (4-40)•10 3 .. Molecular weight makes it possible to provide medicinal preparations. Copolymers are prepared by copolymerization in organic solvent in inert gas consisting of N-vinyl-2-pyrrilidone, cotricosteroid and crotonic acid 21-cronotate or N, N-diethyl aminoethyl crotonate in the presence of radical initiator. Ratio of comonomers, mole%: 17.9-91.9:4.7-19.0:2.4-64.0, respectively. Total concentration of comonomers is 6-55 wt.-%. Solvent is ethanol, 2-propanol, benzene, N,N-dimethyl formamide. Resulting copolymers have improved stability to hydrolysis: under sealing conditions hydrolysis of steroid group does not occur during one-year-storage; derivative prepared by known method cleaves 28-30% of steroid for 6 months under the same conditions. EFFECT: improved properties. 5 cl, 2 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2757274-C2 |
| priorityDate | 1993-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.