http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2063979-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b50acb04c7ceb3c32ed29ac799b0ed48 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00 |
| filingDate | 1992-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f2fa23c32159dc1eaa595c7b7041eb6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8d14798629fffc5f466e10da53a133b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5a8ddafd32e22e0e009eb5058b2e9e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc80e4d476350638b9119b23af538142 |
| publicationDate | 1996-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2063979-C1 |
| titleOfInvention | Peptide showing oxitocin sequence |
| abstract | FIELD: protein chemistry, peptides. SUBSTANCE: product: peptides of oxytocin sequence of the general formula: Boc-A-Cys-(Trt)-Pro-Leu-Gly-NH 2 where A - Asn (1), Ile-Gln-Asn (2), Cys-(Trt)-Tyr-Ile-Gln-Asn (3). Intermediate compounds in oxytocin synthesis were synthesized by condensation of C-terminal tripeptide with corresponding peptide derivative by activated ether method using dicyclohexylcarbodiimide and hydroxybenzotriazole. After removal of Boc-protecting group the synthesized pentapeptide is used for synthesis of compound (2) by condensation of compound (1) with corresponding dipeptide derivative by similar method. New hexapeptide is used after removal of Boc-protecting group for synthesis of oxytocin nonapeptide by coupling with corresponding dipeptide by activated ether method. Oxytocin properties: (α) 20 D = -28 degree (c = 1.1% AcOH), biological activity is 250-390 U/mg. Synthesized peptide is used in chemistry, biology and medicine for oxytocin synthesis. EFFECT: improved method of synthesis. 4 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8778881-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9050286-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2696276-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8148319-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8883965-B2 |
| priorityDate | 1992-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.