http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2060252-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e6978a9d466aeb9321731deef9295dd |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 |
| filingDate | 1993-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1996-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_801a6502956bada8ed1149a641041994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e6fa8fbf0db35e01c1a3e40ca28291e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99a5163653b3b4b85f5687ab63cd1544 |
| publicationDate | 1996-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2060252-C1 |
| titleOfInvention | DERIVATIVES OF N-(2,4- OR 2,5-DISUBSTITUTED TETRAHYDROFURYLALKYL)-N-(PHENYLETHYL-β-OL)-AMINE IN RACEMIC OR ENANTIOMERIC FORM, OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION |
| abstract | FIELD: organic chemistry, medicine as agonists of b-adrenergic receptors. SUBSTANCE: product: derivatives of N-(2,4- or 2,5-disubstituted tetrahydrofurylalkyl)-N-(phenylethyl-b-ol)-amine in racenic or enantiomeric form of the formula (I) given in description text where R - b-alkyl, pyridyl, thienyl or unsubstituted phenyl or that substituted with halogen atom, C 1 -C 10 -alkoxy-group, or C 1 -C 5 -alkylsulfonyl group; n= 1-10, or their pharmaceutically acceptable salts, method of their synthesis and pharmaceutical composition prepared on their base. Reagent 1: substituted benzylamine of the formula (III) indicated in description text. Reagent 2: methyl-5-bromoacetylsalicylate. Process conditions: in the medium of protonic solvent or acetonitrile in the presence of triethylamine, at temperature from the room one to the boiling point of reaction mixture, for 2-18 hr. Reagent 3: compound of the formula (IV) indicated in description text. Reagent 4: sodium hydride as a reductant. Process conditions: in inert atmosphere, at temperature from 0 C to the room one, for 2-8 hr followed by debenzylation of synthesized compound of the formula (V) indicated in description text by hydrogenation in the presence of catalyst Pd/C or C 1 -C 5 , under pressure 2-5.5 bars, at the range of temperature from the room one to 40 C, for from 10 min to 5 hr. EFFECT: improved method of synthesis. 6 cl, 3 tbl |
| priorityDate | 1992-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 109.