http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2059720-C1

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filingDate 1993-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1996-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfc5e2980a3b38e7528c36057d951a12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81bc0a902adfe820ab7ad25b05f4c683
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publicationDate 1996-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2059720-C1
titleOfInvention Strain of hybrid cultured murine cells mus musculus l used for preparing monoclonal antibodies to the human thyrotropic hormone
abstract FIELD: medicinal biotechnology. SUBSTANCE: method involves the preparing strain of hybrid cultured murine cells producing high-affinitive monoclonal antibodies to the human thyrotropic hormone. Strain is obtained by hybridization of murine splenocytes (strain Balb/c) with myeloma cells X63 Ag. 653. Monoclonal antibodies belong to isotype Ig G1, their concentration in cultural fluid and ascitic fluid is 15-20 mcg/ml and 5-10 mg/ml, respectively. Developed test-system based on the obtained monoclonal antibodies ensures to assay the human thyrotropic hormone in human biological fluids at the range of concentrations 2.4-50.0 mc IU/ml. Method can be used for disease diagnosis in endocrinology. EFFECT: improved method of hormone assay. 2 tbl, 2 dwg
priorityDate 1993-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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