| abstract |
FIELD: organic chemistry. SUBSTANCE: products: bicyclic heterocyclic compounds of the formula A 1 -X 1 -Arc(OR 1 ,R 3 )-R 2 where A - a direct bond with X or (1-3c)-alkylene, X 1 - hydroxy, thio, sulfinyl, sulfonyl, Ar - phenylene that can be substituted with halogen, hydroxy, amine, C 1 -C 4 -alkylamine, fluoro-C 1 -C 4 -alkyl, R 1 - C 1 -C 4 -alkyl, C 3 -C 4 -alkenyl, C 3 -C 4 -alkynyl; R 2 and R 3 together form the group of the formula A 2 -X 2 -A 3 which together with carbon atom to which A 2 and A 3 are bound form the ring consisting of 5 or 6 ring atoms in which A 2 and A 3 are (1-3c)-alkylene, X - hydroxy-group. Reagent 1: O-A 1 -X 1 -H. Reagent 2: ZAr-C(OR 1 ,R 3 )R 2 , Z - substituted group. Synthesized compounds were used in medicine as drugs. EFFECT: improved method of synthesis. 1 cl, 5 dwg, 1 tbl |