| abstract |
FIELD: medicine. SUBSTANCE: the use of 9-diethylaminoethyl-2-phenylimidazo-[1,2-a]-benzimidazole nitrate exhibits an expressed inhibiting effect on hydrochloric acid and pepsin secretion that is accompanied with significant antiulcer action. At 7 hr pylorus ligation activity of proposed agent is 46 and 28.4-fold as compared with that for cimetidine and omeprazole, respectively, and by therapeutic index - by 10.5 and 55-fold, respectively. Agent decreases ulcer formation in stomach mucosa, and antiulcer effect of agent is enhanced. EFFECT: enhanced effectiveness of agent proposed. 2 dwg, 10 tbl |